toxemia

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	402
interventional	209
Observational	172
Registry	21

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	70
Drug|placebo	41
Other	31
Procedure	12
Device	10
Behavioral	7
Diagnostic Test	5
Dietary Supplement	5
Biological	4
Drug|Other	4
Biological|Other	3
Dietary Supplement|placebo	3
Behavioral|Drug	2
Device|Other	2
Drug|Procedure	2
Behavioral|Other	1
Biological|placebo	1
Combination Product	1
Combination Product|Drug	1
Diagnostic Test|Other	1
Drug|Other|Procedure	1
Drug|placebo|Procedure	1
Other|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	47
China	16
NA	16
France	12
Germany	11
Egypt	7
Canada	6
Italy	6
Thailand	6
Brazil	5
Netherlands	5
Greece	4
Spain	4
Bangladesh	3
India	3
Switzerland	3
United Kingdom	3
Argentina	2
Ghana	2
Japan	2
Kenya	2
Pakistan	2
Peru	2
Singapore	2
United States|Canada	2
Argentina|Australia|Austria|Belgium|Brazil|Canada|Chile|Czech Republic|Denmark|Egypt|Finland|France	1
Australia	1
Australia|Belgium|Canada|Czech Republic|Finland|France|Spain	1
Austria	1
Austria|Belgium|Poland|Portugal|United States|Argentina|Australia|Brazil|Canada|Chile|Czechia|France|Germany|Hong Kong|Israel|Italy|Japan|Korea, Republic of|Netherlands|South Africa|Spain|Switzerland|Taiwan|United Kingdom	1
Belgium	1
Belgium|Netherlands	1
Burkina Faso|Gambia	1
Colombia	1
Czechia	1
Denmark|Finland|Iceland|Norway	1
Finland	1
France|Germany	1
Georgia|Kazakhstan|Moldova, Republic of|Ukraine|Uzbekistan	1
Germany|Greece	1
Hungary	1
Indonesia	1
Iran, Islamic Republic of	1
Israel	1
Jordan	1
Mexico	1
Norway	1
Panama	1
Saudi Arabia	1
Taiwan	1
Turkey	1
United States|Argentina|Australia|Belgium|Brazil|Bulgaria|Canada|Croatia|Czechia|Finland|France|Germany|Hungary|India|Israel|Korea, Republic of|Netherlands|New Zealand|Peru|Russian Federation|Serbia|Spain|Taiwan|United Kingdom	1
United States|Australia|Austria|Belgium|Canada|Czech Republic|Finland|Germany|Israel|Italy|Japan|Netherlands|New Zealand|Puerto Rico|Spain|Sweden|United Kingdom	1
United States|Australia|Chile|France|Germany|Italy|Mexico|Poland|Slovakia|Switzerland|United Kingdom	1
United States|Belgium|Canada|Finland|France|Germany|Puerto Rico|Spain|United Kingdom	1
United States|Belgium|Hungary|Netherlands|Poland	1
United States|Canada|France|Germany|Spain	1
United States|Canada|Malaysia|Thailand	1
United States|France	1
United States|France|Argentina|Australia|Austria|Belgium|Brazil|Canada|Chile|Czechia|Estonia|Finland|Germany|Greece|Hong Kong|Hungary|India|Israel|Korea, Republic of|Latvia|Malaysia|Netherlands|New Zealand|Portugal|Puerto Rico|Romania|Russian Federation|Slovenia|South Africa|Spain|Sweden|Taiwan|Thailand|United Kingdom	1
United States|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	140
2	9
3	10
5	5
6	4
7	2
8	1
10	2
12	4
13	4
15	1
16	2
17	2
18	2
24	1
26	1
27	1
31	1
34	2
35	1
42	1
43	1
47	1
51	1
52	2
62	1
71	1
87	1
93	1
145	1
161	1
251	1
390	1

Phase

Phase	Study_Count
N/A	86
Phase 3	39
Phase 2	34
Phase 4	30
Phase 2/Phase 3	7
Phase 1	6
Phase 1/Phase 2	6
Early Phase 1	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	27
2	132
3	19
4	8
5	1
6	2
12	1
NA	19

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	8	15.00	10.00000	10.00000	20.0000	50.0000	4.0000	9.0000
1st Qu.	8	77.00	36.50000	13.75000	38.0000	70.0000	120.0000	51.2500
Median	8	146.50	41.00000	21.50000	64.0000	150.0000	322.5000	125.0000
Mean	8	9489.86	39.66667	97.66667	176.5312	331.2857	876.6053	315.1333
3rd Qu.	8	577.50	48.50000	47.25000	190.0000	200.0000	675.0000	211.2500
Max.	8	530000.00	60.00000	466.00000	1415.0000	1579.0000	12500.0000	2040.0000

Trial Group Type

group_type	Group_Count
Experimental	174
Active Comparator	97
Placebo Comparator	78
No Intervention	36
Other	19
NA	19
Sham Comparator	5

Intervention Model

intervention_model	Study_Count
Parallel Assignment	156
Single Group Assignment	36
Crossover Assignment	6
Factorial Assignment	5
Sequential Assignment	3
NA	3

Primary Purpose

primary_purpose	Study_Count
Treatment	142
Prevention	21
Diagnostic	17
Health Services Research	9
Screening	6
Supportive Care	4
NA	4
Basic Science	3
Other	3

Observational Studies

Studies by Country

Country	Study_Count
United States	40
China	19
NA	14
Germany	12
France	11
Taiwan	6
United Kingdom	6
Egypt	5
Italy	5
Sweden	4
Czechia	3
Greece	3
Israel	3
Belgium	2
Canada	2
Hong Kong	2
India	2
Korea, Republic of	2
Lithuania	2
Singapore	2
Thailand	2
Turkey	2
United States|Canada	2
Argentina	1
Bangladesh	1
Belgium|France	1
Belgium|France|Germany|Italy|Netherlands	1
Belgium|France|Spain|Switzerland	1
Canada|New Zealand|United Kingdom	1
Denmark	1
Finland	1
France|Italy|Switzerland|United Kingdom	1
France|Spain	1
Indonesia|Thailand|Vietnam	1
Malaysia	1
Pakistan	1
Slovakia	1
South Africa	1
Suriname	1
Switzerland	1
United States|Australia|Canada|Colombia|Netherlands	1
United States|Canada|Israel|Singapore|United Kingdom	1
United States|Greece	1
United States|Sweden	1

Sites per Study

Site_count	Study_Count
1	127
2	13
3	5
4	2
5	8
6	1
7	4
9	1
13	1
14	2
15	1
16	1
19	1
20	1
21	1
24	1
27	1
52	1

Enrollment Metrics

Measure	Observational
Min	4.000
1st Qu	77.000
Median	200.000
Mean	2196.918
3rd Qu	601.500
Max	252245.000

Observation Model

observational_model	Study_Count
Cohort	105
Case-Only	25
Case-Control	18
Other	10
Case Control	9
NA	4
Defined Population	1

Time Perspective

time_perspective	Study_Count
Prospective	143
Retrospective	17
Other	5
Cross-Sectional	4
NA	2
Cross-Sectional, Retrospective/Prospective	1

Registries

Studies by Country

Country	Study_Count
NA	5
China	4
Norway	3
France	2
Belgium	1
Czechia	1
Egypt	1
Germany	1
Korea, Republic of	1
Thailand	1
United States	1

Sites per Study

Site_count	Study_Count
1	18
3	2
4	1

Enrollment Metrics

Measure	Registries
Min	1.000
1st Qu	60.000
Median	175.000
Mean	1755.952
3rd Qu	458.000
Max	20000.000

Registry Model

observational_model	Study_Count
Cohort	9
Case-Control	8
Case-Only	3
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	19
Cross-Sectional	1
Other	1

Follow-up

target_duration	Study_Count
1 Month	4
1 Day	3
1 Year	3
3 Months	3
28 Days	2
12 Months	1
2 Months	1
20 Years	1
4 Weeks	1
7 Days	1
90 Days	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04459572	As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR	https://ClinicalTrials.gov/show/NCT04459572	Completed	Ege University	2019-09-27
NCT02376842	Study of an Electronic Health Record-embedded Severe Sepsis Early Warning Alert	https://ClinicalTrials.gov/show/NCT02376842	Completed	Stanford University	2015-03-31
NCT02163174	Pentoxifylline and Late Onset Sepsis in Preterm Infants	https://ClinicalTrials.gov/show/NCT02163174	Completed	Mansoura University	2013-02-28
NCT03403530	Efficacy of IgM Rich Immunoglobulin With Antibiotics for Bacterial Sepsis in Very Low Birth Weight Preterm Neonates	https://ClinicalTrials.gov/show/NCT03403530	Completed	Sir Takhtasinhji General Hospital	2018-06-30
NCT03371680	Kinetics of Surfactant Proteins, Phosphatidylcholine and Body Water in Intensive Care Unit (ICU)	https://ClinicalTrials.gov/show/NCT03371680	Completed	University of Padova	2013-12-31
NCT03821038	Recombinant Interleukin-7 (CYT107) to Restore Absolute Lymphocyte Counts in Sepsis Patients	https://ClinicalTrials.gov/show/NCT03821038	Recruiting	Revimmune	2020-06-30
NCT03332225	A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis	https://ClinicalTrials.gov/show/NCT03332225	Active, not recruiting	Hellenic Institute for the Study of Sepsis	2019-12-03
NCT03295825	Heparin Binding Protein in Early Sepsis Diagnosis	https://ClinicalTrials.gov/show/NCT03295825	Completed	Hellenic Institute for the Study of Sepsis	2018-06-30
NCT03295162	Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT03295162	Completed	Ain Shams University	2017-03-01
NCT03277677	The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients	https://ClinicalTrials.gov/show/NCT03277677	Recruiting	Chulalongkorn University	2018-07-01
NCT03275090	The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis	https://ClinicalTrials.gov/show/NCT03275090	Completed	Mansoura University Children Hospital	2017-01-02
NCT03258684	Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT03258684	Completed	Zhujiang Hospital	2019-02-02
NCT03256461	Lactate Clearance Goal-directed Therapy in Sepsis	https://ClinicalTrials.gov/show/NCT03256461	Recruiting	Nanfang Hospital of Southern Medical University	2020-12-31
NCT03246893	Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients	https://ClinicalTrials.gov/show/NCT03246893	Recruiting	Mahidol University	2020-04-30
NCT03238742	The Efficacy of Xuebijing Injection on Sepsis	https://ClinicalTrials.gov/show/NCT03238742	Recruiting	Southeast University, China	2019-12-31
NCT03237728	Study of Multiple-dose Kukoamine B Mesilate in Sepsis Patients	https://ClinicalTrials.gov/show/NCT03237728	Completed	Tianjin Chasesun Pharmaceutical Co., LTD	2019-09-25
NCT03199547	Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death	https://ClinicalTrials.gov/show/NCT03199547	Recruiting	London School of Hygiene and Tropical Medicine	2020-12-31
NCT03175328	CRRT Timing in Sepsis-associated AKI in ICU	https://ClinicalTrials.gov/show/NCT03175328	Recruiting	Second Affiliated Hospital of Guangzhou Medical University	2022-02-28
NCT03152474	Adrenal Cortical Function and Vitamin A Deficiency in Sepsis	https://ClinicalTrials.gov/show/NCT03152474	Completed	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center	2000-01-31
NCT03137446	Restrictive Intravenous Fluids Trial in Sepsis	https://ClinicalTrials.gov/show/NCT03137446	Completed	Rhode Island Hospital	2018-03-30
NCT03129542	Midodrine Hydrochloride in Early Sepsis	https://ClinicalTrials.gov/show/NCT03129542	Recruiting	Mayo Clinic	2020-07-31
NCT03078335	Glove-based Care in the NICU to Prevent Late Onset Sepsis	https://ClinicalTrials.gov/show/NCT03078335	Completed	Hamilton Health Sciences Corporation	2018-06-01
NCT03068741	Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)	https://ClinicalTrials.gov/show/NCT03068741	Recruiting	Sunnybrook Health Sciences Centre	2024-03-31
NCT03048994	Glutamine Supplementation in Critically Ill Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT03048994	Completed	Changi General Hospital	2013-06-30
NCT03019965	Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis	https://ClinicalTrials.gov/show/NCT03019965	Completed	Coordinación de Investigación en Salud, Mexico	2019-07-30
NCT02972827	Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02972827	Recruiting	Santa Barbara Cottage Hospital	2020-05-31
NCT02960854	A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock.	https://ClinicalTrials.gov/show/NCT02960854	Completed	Bristol-Myers Squibb	2018-01-05
NCT02959229	Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT02959229	Completed	Ain Shams University	2015-12-31
NCT02954926	Intravenous Immunoglobulin in Prevention of Preterm Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT02954926	Completed	Hormozgan University of Medical Sciences	2016-10-31
NCT02927054	Effect of Education on Resident Physician Knowledge of Sepsis	https://ClinicalTrials.gov/show/NCT02927054	Completed	University of Utah	2016-09-30
NCT02899143	Short-course Antimicrobial Therapy in Sepsis	https://ClinicalTrials.gov/show/NCT02899143	Recruiting	Ospedale Santa Maria delle Croci	2019-12-31
NCT02898961	Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02898961	Completed	Centre Hospitalier Universitaire de NÄ«mes	2015-02-28
NCT02891174	The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy	https://ClinicalTrials.gov/show/NCT02891174	Completed	University of Michigan	2018-03-31
NCT02883595	Efficacy of Thymosin Alpha 1 on Improving Monocyte Function for Sepsis	https://ClinicalTrials.gov/show/NCT02883595	Completed	Sun Yat-sen University	2016-09-30
NCT02871544	Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis	https://ClinicalTrials.gov/show/NCT02871544	Completed	Southeast University, China	2016-02-29
NCT02867267	The Efficacy and Safety of Ta1 for Sepsis	https://ClinicalTrials.gov/show/NCT02867267	Recruiting	Sun Yat-sen University	2020-12-31
NCT02837731	Fluid Responsiveness Evaluation in Sepsis-associated Hypotension	https://ClinicalTrials.gov/show/NCT02837731	Completed	Cheetah Medical Inc.	2019-03-31
NCT02820675	Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions	https://ClinicalTrials.gov/show/NCT02820675	Recruiting	Center for Sepsis Control and Care, Germany	2019-07-31
NCT02794025	The Effect of Esmolol on Clinical Prognosis of Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02794025	Completed	Fujian Provincial Hospital	2013-01-31
NCT02789995	Dysfunctions of Human Muscle Stem Cells in Sepsis	https://ClinicalTrials.gov/show/NCT02789995	Completed	Institut Pasteur	2018-06-28
NCT02748382	Fluids in Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02748382	Completed	McMaster University	2017-08-19
NCT02747121	Effects of External Inspection on Sepsis Detection and Treatment	https://ClinicalTrials.gov/show/NCT02747121	Recruiting	Norwegian Board of Health Supervision	2020-12-31
NCT02734550	(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis	https://ClinicalTrials.gov/show/NCT02734550	Completed	Center for Sepsis Control and Care, Germany	2019-08-22
NCT02734147	High Dose Intravenous Ascorbic Acid in Severe Sepsis	https://ClinicalTrials.gov/show/NCT02734147	Completed	Christiana Care Health Services	2017-10-08
NCT02730624	Piperacillin/Tazobactam in Critically Ill Patients With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02730624	Completed	Prince of Songkla University	2016-05-31
NCT02721134	Diagnostic Performance of a New Bio-marker During Bacterial Sepsis	https://ClinicalTrials.gov/show/NCT02721134	Recruiting	Centre Hospitalier Universitaire de Nice	2018-05-31
NCT02707497	The Effect of REcombinant Human Thrombopoietin (rhTPO) on Sepsis Patients With aCUte Severe thrombocytopEnia	https://ClinicalTrials.gov/show/NCT02707497	Recruiting	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	2021-10-31
NCT02647554	Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China	https://ClinicalTrials.gov/show/NCT02647554	Recruiting	Peking Union Medical College Hospital	2020-05-31
NCT02640807	A Study of IL-7 to Restore Absolute Lymphocyte Counts in Sepsis Patients	https://ClinicalTrials.gov/show/NCT02640807	Completed	Revimmune	2018-08-27
NCT03090919	The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis	https://ClinicalTrials.gov/show/NCT03090919	Recruiting	University of Kentucky	2020-12-31
NCT03389555	Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial	https://ClinicalTrials.gov/show/NCT03389555	Recruiting	Beth Israel Deaconess Medical Center	2019-12-30
NCT02503761	Bolus Versus Prolonged Infusion of Meropenem in Newborn With Late Onset Sepsis	https://ClinicalTrials.gov/show/NCT02503761	Completed	Mansoura University	2015-06-30
NCT02474797	Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT02474797	Completed	Groupe Hospitalier Paris Saint Joseph	2019-07-08
NCT02473263	Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock	https://ClinicalTrials.gov/show/NCT02473263	Active, not recruiting	Assistance Publique - Hôpitaux de Paris	2019-02-09
NCT02469571	Modulation of Gut Microbiota in Early Sepsis: A Pilot Study	https://ClinicalTrials.gov/show/NCT02469571	Completed	Medical University of Graz	2016-07-31
NCT02399397	Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics	https://ClinicalTrials.gov/show/NCT02399397	Completed	Universidade Estadual Paulista Júlio de Mesquita Filho	2015-12-31
NCT02378545	Trial of Hyperoxic O2 Therapy vs. Normoxic O2 Therapy in Sepsis	https://ClinicalTrials.gov/show/NCT02378545	Completed	University Hospital Plymouth NHS Trust	2016-10-31
NCT02354742	Echo vs. EGDT in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02354742	Completed	Intermountain Health Care, Inc.	2017-05-31
NCT02346331	Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya	https://ClinicalTrials.gov/show/NCT02346331	Completed	Duke University	2016-08-31
NCT02330432	Mycobacterium w in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02330432	Recruiting	Postgraduate Institute of Medical Education and Research	2019-01-31
NCT02325258	Assessment of a Proposed Microbiological Alert and Its Impact on a Sepsis Campaign	https://ClinicalTrials.gov/show/NCT02325258	Completed	Hospital General Universitario Gregorio Marañon	2013-01-31
NCT02295514	Correlation Between PTP1B Expression and Organ Failure During Sepsis	https://ClinicalTrials.gov/show/NCT02295514	Completed	University Hospital, Rouen	2016-05-31
NCT03385850	The Th17/Treg Cells and IL-23/IL-17 Axis and Early Enteral Nutrition in Sepsis	https://ClinicalTrials.gov/show/NCT03385850	Completed	Nanjing First Hospital, Nanjing Medical University	2018-06-30
NCT02276066	Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS	https://ClinicalTrials.gov/show/NCT02276066	Active, not recruiting	University of Florida	2019-11-20
NCT02273843	A Trial on Different Dosages of Vitamin D in Preterm Infants With Late-onset Sepsis	https://ClinicalTrials.gov/show/NCT02273843	Completed	Mansoura University Children Hospital	2015-08-31
NCT02213796	Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units	https://ClinicalTrials.gov/show/NCT02213796	Completed	Prince of Songkla University	2013-12-31
NCT02159079	A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study)	https://ClinicalTrials.gov/show/NCT02159079	Completed	Vanderbilt University Medical Center	2016-02-29
NCT02135770	Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis	https://ClinicalTrials.gov/show/NCT02135770	Completed	Indonesia University	2014-06-30
NCT02106975	Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury	https://ClinicalTrials.gov/show/NCT02106975	Completed	Virginia Commonwealth University	2017-11-16
NCT01284452	Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)	https://ClinicalTrials.gov/show/NCT01284452	Completed	Mahidol University	2014-12-31
NCT01275638	The Effect of Moderate-Dose Steroid Therapy in Sepsis	https://ClinicalTrials.gov/show/NCT01275638	Completed	TC Erciyes University	2008-05-31
NCT01988428	Prehospital Antibiotics Against Sepsis Trial	https://ClinicalTrials.gov/show/NCT01988428	Completed	VU University Medical Center	2017-06-30
NCT01948063	Ubiquinol (Reduced COQ10) for Patients With Sepsis	https://ClinicalTrials.gov/show/NCT01948063	Completed	Beth Israel Deaconess Medical Center	2014-04-30
NCT01867138	Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin	https://ClinicalTrials.gov/show/NCT01867138	Completed	Hospital Italiano de Buenos Aires	2010-08-31
NCT02025660	Efficacy of Mw Vaccine in Treatment of Severe Sepsis	https://ClinicalTrials.gov/show/NCT02025660	Completed	Postgraduate Institute of Medical Education and Research	2014-02-28
NCT03613714	Innovation in Postpartum Care for Women With Hypertensive Disorders of Pregnancy	https://ClinicalTrials.gov/show/NCT03613714	Completed	University of North Carolina, Chapel Hill	2019-12-31
NCT01784159	ASpirin for Patients With SEPsis and SeptIc Shock	https://ClinicalTrials.gov/show/NCT01784159	Recruiting	Federal University of São Paulo	2020-12-31
NCT01775020	Dose-response Study of Arginine Supplementation in Severe Sepsis	https://ClinicalTrials.gov/show/NCT01775020	Completed	Maastricht University Medical Center	2004-05-31
NCT01760967	Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial	https://ClinicalTrials.gov/show/NCT01760967	Completed	Wakayama Medical University	2016-01-31
NCT01751945	Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project	https://ClinicalTrials.gov/show/NCT01751945	Completed	Aga Khan University	2013-12-31
NCT01739361	Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis	https://ClinicalTrials.gov/show/NCT01739361	Completed	Vanderbilt University Medical Center	2013-12-31
NCT03350113	Hemospec Device for Sepsis Diagnosis	https://ClinicalTrials.gov/show/NCT03350113	Completed	University of Athens	2018-04-30
NCT01689441	Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis	https://ClinicalTrials.gov/show/NCT01689441	Completed	Brigham and Women’s Hospital	2014-02-28
NCT01649921	The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis	https://ClinicalTrials.gov/show/NCT01649921	Completed	Radboud University	2016-12-31
NCT01626612	De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis	https://ClinicalTrials.gov/show/NCT01626612	Completed	Assistance Publique Hopitaux De Marseille	2013-04-30
NCT01598831	Phase 3 Safety and Efficacy Study of ART-123 in Subjects With Severe Sepsis and Coagulopathy	https://ClinicalTrials.gov/show/NCT01598831	Completed	Asahi Kasei Pharma America Corporation	2018-04-05
NCT01568853	A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis	https://ClinicalTrials.gov/show/NCT01568853	Completed	Jinling Hospital, China	2012-03-31
NCT03344627	Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03344627	Completed	Mahidol University	2018-11-30
NCT01551394	Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis	https://ClinicalTrials.gov/show/NCT01551394	Completed	PENTA Foundation	2014-12-31
NCT01525316	Lactoferrin for Prevention of Sepsis in Infants	https://ClinicalTrials.gov/show/NCT01525316	Completed	Universidad Peruana Cayetano Heredia	2016-10-31
NCT01484106	Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Severe Sepsis	https://ClinicalTrials.gov/show/NCT01484106	Completed	Cheetah Medical Inc.	2014-08-31
NCT01474863	Citrulline in Severe Sepsis	https://ClinicalTrials.gov/show/NCT01474863	Completed	Vanderbilt University Medical Center	2016-03-31
NCT01453270	Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial	https://ClinicalTrials.gov/show/NCT01453270	Completed	National University Hospital, Singapore	2014-03-31
NCT01450358	Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture.	https://ClinicalTrials.gov/show/NCT01450358	Completed	Instituto do Coracao	2016-05-31
NCT01449721	Preemptive Resuscitation for Eradication of Septic Shock	https://ClinicalTrials.gov/show/NCT01449721	Completed	Christiana Care Health Services	2015-01-31
NCT01434121	Ascorbic Acid (Vitamin C) Infusion in Human Sepsis	https://ClinicalTrials.gov/show/NCT01434121	Completed	Virginia Commonwealth University	2012-09-30
NCT01411670	Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock.	https://ClinicalTrials.gov/show/NCT01411670	Completed	University of Roma La Sapienza	2015-02-28
NCT01352182	Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT01352182	Completed	Children’s Hospital Medical Center, Cincinnati	2016-05-31
NCT04303871	Invasive Versus Non-invasive Assessment of Blood Pressure in Hypertensive Disorders of Pregnancy	https://ClinicalTrials.gov/show/NCT04303871	Completed	Assiut University	2020-03-01
NCT04280497	Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis	https://ClinicalTrials.gov/show/NCT04280497	Recruiting	Assistance Publique - Hôpitaux de Paris	2024-10-31
NCT04227652	Control of Fever in Septic Patients	https://ClinicalTrials.gov/show/NCT04227652	Completed	University Hospital Ostrava	2019-02-28
NCT04216459	Effect of Anti-inflammatory and Anti-microbial Co-supplementations in Traumatic ICU Patients at High Risk of Sepsis	https://ClinicalTrials.gov/show/NCT04216459	Recruiting	Mansoura University	2020-07-31
NCT04160676	Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT04160676	Recruiting	Tanta University	2020-11-30
NCT04152980	Pentoxifylline Dose Optimization in Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT04152980	Recruiting	Erasmus Medical Center	2020-12-31
NCT04148989	Effects of Code Sepsis Implementation on Emergency Department (ED) Sepsis Care	https://ClinicalTrials.gov/show/NCT04148989	Enrolling by invitation	Intermountain Health Care, Inc.	2021-03-31
NCT04134624	EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT04134624	Enrolling by invitation	HealthPartners Institute	2021-01-31
NCT04130230	Adjuvant Use of Neostigmine in Sepsis and Septic Shock.	https://ClinicalTrials.gov/show/NCT04130230	Recruiting	Mansoura University	2020-03-31
NCT04111822	Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT04111822	Recruiting	Institut d’Investigació Biomèdica de Girona Dr. Josep Trueta	2020-10-31
NCT04078594	Electronic Early Notification of Sepsis in Hospitalized Ward Patients	https://ClinicalTrials.gov/show/NCT04078594	Recruiting	King Abdullah International Medical Research Center	2021-10-30
NCT03769844	GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study	https://ClinicalTrials.gov/show/NCT03769844	Recruiting	Nationwide Children’s Hospital	2021-12-05
NCT03960203	Effect of a Sepsis Prediction Algorithm on Clinical Outcomes	https://ClinicalTrials.gov/show/NCT03960203	Completed	Dascena	2018-06-30
NCT03925857	Prevention of Sepsis-related Organ Dysfunction With Allocetra-OTS	https://ClinicalTrials.gov/show/NCT03925857	Completed	Enlivex Therapeutics Ltd.	2019-12-10
NCT03924518	Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock	https://ClinicalTrials.gov/show/NCT03924518	Recruiting	Zhujiang Hospital	2020-12-31
NCT03869073	Evolocumab for PCSK9 Lowering in Early Acute Sepsis (The PLEASe Study)	https://ClinicalTrials.gov/show/NCT03869073	Recruiting	University of British Columbia	2021-02-11
NCT03865602	Improving Morbidity During Post-Acute Care Transitions for Sepsis	https://ClinicalTrials.gov/show/NCT03865602	Recruiting	Atrium Health	2019-12-31
NCT03829683	Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis	https://ClinicalTrials.gov/show/NCT03829683	Recruiting	Virginia Commonwealth University	2021-02-28
NCT03791866	The Th9/IL-9 and Early Enteral Nutrition in Sepsis	https://ClinicalTrials.gov/show/NCT03791866	Recruiting	Nanjing First Hospital, Nanjing Medical University	2019-12-31
NCT03755635	Neonatal Sepsis at Neonatal Intensive Care Units in Ghana	https://ClinicalTrials.gov/show/NCT03755635	Recruiting	University of Copenhagen	2020-01-01
NCT03754257	Effects of High-frequency Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT03754257	Recruiting	Hospital Sirio-Libanes	2021-04-01
NCT03749746	Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia	https://ClinicalTrials.gov/show/NCT03749746	Recruiting	University of Pittsburgh	2021-12-31
NCT03730636	Procalcitonin and Duration of AntiBiotherapy In Late Onset Sepsis of Neonate	https://ClinicalTrials.gov/show/NCT03730636	Recruiting	Assistance Publique - Hôpitaux de Paris	2021-06-30
NCT03728790	Remote BP Monitoring in the PP Period	https://ClinicalTrials.gov/show/NCT03728790	Active, not recruiting	Columbia University	2019-07-28
NCT03714841	C-reactive Protein Information and Blood Cultures for Emergency Department Patients With Sepsis	https://ClinicalTrials.gov/show/NCT03714841	Recruiting	University of British Columbia	2019-09-15
NCT03685214	Comparison of Balanced Crystalloids and Normal Saline in Septic Patients	https://ClinicalTrials.gov/show/NCT03685214	Recruiting	Zhongnan Hospital	2021-04-30
NCT03655626	Implementation and Evaluations of Sepsis Watch	https://ClinicalTrials.gov/show/NCT03655626	Completed	Duke University	2019-07-05
NCT03592277	Vitamin C & Thiamine in Sepsis	https://ClinicalTrials.gov/show/NCT03592277	Recruiting	Saint Francis Care	2020-06-01
NCT03565159	Pneumococcal Vaccination to Accelerate Immune Recovery in Sepsis Survivors	https://ClinicalTrials.gov/show/NCT03565159	Recruiting	Guy’s and St Thomas’ NHS Foundation Trust	2021-01-31
NCT03509350	Vitamin C, Thiamine, and Steroids in Sepsis	https://ClinicalTrials.gov/show/NCT03509350	Completed	Emory University	2019-08-22
NCT03497182	Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis	https://ClinicalTrials.gov/show/NCT03497182	Completed	Landon Pediatric Foundation	2018-10-06
NCT03472170	Clinical Trial for Valuation of the Effectiveness of Lactoferrine in the Prevention of Sepsis in New Premature Born. Bimonitorization of the Antinflammatory Mechanisms, Antioxidants and the Intestinal Microbiote.	https://ClinicalTrials.gov/show/NCT03472170	Recruiting	Maimónides Biomedical Research Institute of Córdoba	2020-03-01
NCT03454087	Study of Early Enteral Dextrose in Sepsis	https://ClinicalTrials.gov/show/NCT03454087	Completed	University of Pittsburgh	2020-03-02
NCT03453177	Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis	https://ClinicalTrials.gov/show/NCT03453177	Completed	Drugs for Neglected Diseases	2019-03-14
NCT03452865	Esomeprazole to Reduce Organ Failure in Sepsis	https://ClinicalTrials.gov/show/NCT03452865	Recruiting	Università Vita-Salute San Raffaele	2022-03-31
NCT03422159	Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.	https://ClinicalTrials.gov/show/NCT03422159	Completed	Community Medical Center, Toms River, NJ	2019-06-05
NCT01264536	Pilot Study: Lactoferrin for Prevention of Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT01264536	Completed	Universidad Peruana Cayetano Heredia	2011-10-31
NCT01247792	End-of-life Decision-making in Patients With Sepsis-related Organ Failure	https://ClinicalTrials.gov/show/NCT01247792	Completed	Center for Sepsis Control and Care, Germany	2014-09-30
NCT01223690	Clarithromycin as Immunomodulator for the Management of Sepsis	https://ClinicalTrials.gov/show/NCT01223690	Completed	University of Athens	2010-11-30
NCT01187134	Medical Education for Sepsis Source Control and Antibiotics	https://ClinicalTrials.gov/show/NCT01187134	Completed	Center for Sepsis Control and Care, Germany	2013-06-30
NCT01145560	A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFabâ„¢) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock	https://ClinicalTrials.gov/show/NCT01145560	Completed	AstraZeneca	2012-05-31
NCT01144624	A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFabâ„¢) in Japanese With Severe Sepsis/Septic Shock	https://ClinicalTrials.gov/show/NCT01144624	Completed	AstraZeneca	2011-08-31
NCT01139489	Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU’s)	https://ClinicalTrials.gov/show/NCT01139489	Completed	VU University Medical Center	2014-08-31
NCT01089361	Immunomodulatory Properties of Ketamine in Sepsis	https://ClinicalTrials.gov/show/NCT01089361	Completed	Beth Israel Deaconess Medical Center	2010-06-30
NCT01069146	Mild Therapeutic Hypothermia During Severe Sepsis	https://ClinicalTrials.gov/show/NCT01069146	Completed	University Hospital, Brest	2005-01-31
NCT01027897	Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients	https://ClinicalTrials.gov/show/NCT01027897	Completed	Emory University	2011-12-31
NCT01027429	Simplified Antibiotic Therapy for Sepsis in Young Infants	https://ClinicalTrials.gov/show/NCT01027429	Completed	Aga Khan University	2013-12-31
NCT01013662	Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control	https://ClinicalTrials.gov/show/NCT01013662	Completed	University of Sao Paulo	2007-07-31
NCT00994812	The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS)	https://ClinicalTrials.gov/show/NCT00994812	Completed	University of Oulu	2009-12-31
NCT00962156	Scandinavian Starch for Severe Sepsis/Septic Shock Trial	https://ClinicalTrials.gov/show/NCT00962156	Completed	Scandinavian Critical Care Trials Group	2012-03-31
NCT00926497	Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis	https://ClinicalTrials.gov/show/NCT00926497	Completed	Luzerner Kantonsspital	2006-12-31
NCT00844337	Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh	https://ClinicalTrials.gov/show/NCT00844337	Completed	Johns Hopkins Bloomberg School of Public Health	2013-09-30
NCT04203524	Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis	https://ClinicalTrials.gov/show/NCT04203524	Recruiting	King Hussein Cancer Center	2021-08-21
NCT03334227	High Flow Nasal Cannula in Severe Sepsis	https://ClinicalTrials.gov/show/NCT03334227	Recruiting	Althaia Xarxa Assistencial Universitària de Manresa	2020-02-28
NCT00832039	Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00832039	Completed	Kompetenznetz Sepsis	2013-03-31
NCT03920982	Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.	https://ClinicalTrials.gov/show/NCT03920982	Recruiting	Centre Hospitalier Universitaire, Amiens	2022-04-30
NCT02654561	Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation	https://ClinicalTrials.gov/show/NCT02654561	Recruiting	China Medical University, China	2021-02-28
NCT01538875	Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy	https://ClinicalTrials.gov/show/NCT01538875	Completed	Saint Thomas Hospital, Panama	2013-04-30
NCT03306186	Hemospec Device for the Diagnosis of Sepsis	https://ClinicalTrials.gov/show/NCT03306186	Completed	University of Athens	2017-12-30
NCT02468310	Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana	https://ClinicalTrials.gov/show/NCT02468310	Completed	Julius Global Health	2017-02-09
NCT01333982	Neonatal Sepsis, Evaluation, Bangladesh	https://ClinicalTrials.gov/show/NCT01333982	Completed	International Centre for Diarrhoeal Disease Research, Bangladesh	2013-12-31
NCT03764085	Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Sepsis.	https://ClinicalTrials.gov/show/NCT03764085	Completed	Yuria-Pharm	2019-12-11
NCT03728998	Non-invasive Measurement of CO in Patients With Uncomplicated Sepsis	https://ClinicalTrials.gov/show/NCT03728998	Completed	Medical Centre Leeuwarden	2019-03-23
NCT00772096	Septic Encephalopathy and Late Cognitive Dysfunction	https://ClinicalTrials.gov/show/NCT00772096	Completed	University Hospital, Basel, Switzerland	2011-06-30
NCT00732277	Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study	https://ClinicalTrials.gov/show/NCT00732277	Completed	University Hospital Southampton NHS Foundation Trust	2012-04-30
NCT00711620	Efficacy of Thymosin alpha1 for Severe Sepsis	https://ClinicalTrials.gov/show/NCT00711620	Completed	Sun Yat-sen University	2010-12-31
NCT00707122	Volume Replacement With Albumin in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00707122	Completed	Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico	2013-04-30
NCT00707785	Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis	https://ClinicalTrials.gov/show/NCT00707785	Completed	Johns Hopkins University	2011-04-30
NCT00646399	Safety and Efficacy of Pagibaximab Injection in Very Low Birth Weight Neonates for Prevention of Staphylococcal Sepsis	https://ClinicalTrials.gov/show/NCT00646399	Completed	Biosynexus Incorporated	2011-05-31
NCT00634075	Clinical Assessment of Fish Oil-based Lipid Emulsion Infusions in Critical Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00634075	Completed	Li Shin Hospital	2009-08-31
NCT00630656	Safety and Efficacy Study of Recombinant Human Lactoferrin to Treat Severe Sepsis	https://ClinicalTrials.gov/show/NCT00630656	Completed	Agennix	2009-08-31
NCT00608322	Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis	https://ClinicalTrials.gov/show/NCT00608322	Completed	National Institute of General Medical Sciences (NIGMS)	2013-04-30
NCT00568893	An Open Label Study of Severe Sepsis in Adults	https://ClinicalTrials.gov/show/NCT00568893	Completed	Eli Lilly and Company	NA
NCT00568737	The Study of Drotrecogin Alfa (Activated) in Adult Patients With Severe Sepsis at a Low Risk of Death	https://ClinicalTrials.gov/show/NCT00568737	Completed	Eli Lilly and Company	NA
NCT00559130	Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis	https://ClinicalTrials.gov/show/NCT00559130	Completed	MedaSorb Technologies, Inc	2011-04-30
NCT00537693	Cytokine Removal by CRRT in Pediatric Sepsis	https://ClinicalTrials.gov/show/NCT00537693	Completed	Sunnybrook Health Sciences Centre	2010-04-30
NCT00534287	Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00534287	Completed	Kompetenznetz Sepsis	2010-04-30
NCT00510835	Protocolized Care for Early Septic Shock	https://ClinicalTrials.gov/show/NCT00510835	Completed	University of Pittsburgh	2013-07-31
NCT00487656	Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation	https://ClinicalTrials.gov/show/NCT00487656	Completed	Artisan Pharma, Inc.	2010-05-31
NCT00799916	Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00799916	Completed	Universidad Nacional de La Plata	2009-08-31
NCT00464204	Effects of Voluven on Hemodynamics and Tolerability of Enteral Nutrition in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00464204	Completed	Fresenius Kabi	2010-05-31
NCT00430859	Bovine Intestinal Alkaline Phosphatase for the Treatment of Patients With Sepsis	https://ClinicalTrials.gov/show/NCT00430859	Completed	AM-Pharma	2006-03-31
NCT00406198	Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis	https://ClinicalTrials.gov/show/NCT00406198	Completed	Hopital Lariboisière	NA
NCT00386425	Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated)	https://ClinicalTrials.gov/show/NCT00386425	Completed	Eli Lilly and Company	2009-08-31
NCT00372502	Clinical Trial of the Optimal Endpoint of Early Sepsis Resuscitation	https://ClinicalTrials.gov/show/NCT00372502	Completed	National Institute of General Medical Sciences (NIGMS)	2008-12-31
NCT00346580	The Effects of HIV Protease Inhibitors in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00346580	Completed	Mayo Clinic	2005-09-30
NCT00334828	ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00334828	Completed	Eisai Inc.	2011-01-31
NCT00333593	Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure	https://ClinicalTrials.gov/show/NCT00333593	Completed	Austin Health	NA
NCT00329680	The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis	https://ClinicalTrials.gov/show/NCT00329680	Completed	Fernandes Tavora Hospital	2008-12-31
NCT00318552	Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients.	https://ClinicalTrials.gov/show/NCT00318552	Completed	Pfizer	2006-06-30
NCT03788772	Systems Analysis of Antigen Presenting Cells in Human Sepsis	https://ClinicalTrials.gov/show/NCT03788772	Recruiting	Assistance Publique - Hôpitaux de Paris	2022-07-15
NCT00273728	BaSES Trial: Basel Starch Evaluation in Sepsis	https://ClinicalTrials.gov/show/NCT00273728	Completed	University Hospital, Basel, Switzerland	2010-06-30
NCT00252915	Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00252915	Completed	Charite University, Berlin, Germany	2007-01-31
NCT00222222	Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT00222222	Completed	Universitätsmedizin Mannheim	2011-12-31
NCT00159952	Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00159952	Completed	Policlinico Hospital	2007-03-31
NCT00143611	Efficacy & Safety of Resatorvid in Adults With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00143611	Completed	Takeda	2007-02-28
NCT00142220	The Benefit of Adding Fish Oil to the Nutrition of Critically Ill Patients	https://ClinicalTrials.gov/show/NCT00142220	Completed	University Medicine Greifswald	NA
NCT00138112	Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation	https://ClinicalTrials.gov/show/NCT00138112	Completed	Memorial Sloan Kettering Cancer Center	NA
NCT00135473	Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)	https://ClinicalTrials.gov/show/NCT00135473	Completed	SepNet - Critical Care Trials Group	NA
NCT00113191	Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants	https://ClinicalTrials.gov/show/NCT00113191	Completed	Bristol-Myers Squibb	2006-06-30
NCT00100308	Unfractioned Heparin for Treatment of Sepsis	https://ClinicalTrials.gov/show/NCT00100308	Completed	Universidad de Antioquia	2007-07-31
NCT00049777	A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated)	https://ClinicalTrials.gov/show/NCT00049777	Completed	Eli Lilly and Company	NA
NCT00049764	Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis	https://ClinicalTrials.gov/show/NCT00049764	Completed	Eli Lilly and Company	NA
NCT00046072	A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00046072	Completed	Eisai Inc.	NA
NCT00042588	A Safety and Efficacy Study of Hospitalized Patients With Community-Acquired Pneumonia and Sepsis	https://ClinicalTrials.gov/show/NCT00042588	Completed	ICOS Corporation	NA
NCT00034476	A Phase IIb Study to Determine the Efficacy and Safety of the Study Drug in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00034476	Completed	Eli Lilly and Company	NA
NCT00031512	Pleconaril Enteroviral Sepsis Syndrome	https://ClinicalTrials.gov/show/NCT00031512	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	2010-09-30
NCT00819416	Fluid Resuscitation in Early Septic Shock	https://ClinicalTrials.gov/show/NCT00819416	Completed	Ottawa Hospital Research Institute	2009-10-31
NCT00000543	Oral Calcium in Pregnant Women With Hypertension	https://ClinicalTrials.gov/show/NCT00000543	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA
NCT00089986	GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults	https://ClinicalTrials.gov/show/NCT00089986	Completed	GlaxoSmithKline	2007-04-01
NCT00000534	Calcium for Pre-Eclampsia Prevention (CPEP)	https://ClinicalTrials.gov/show/NCT00000534	Completed	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03356249	Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis	https://ClinicalTrials.gov/show/NCT03356249	Recruiting	University Hospital Heidelberg	2020-12-31
NCT04130789	Personalized Swiss Sepsis Study	https://ClinicalTrials.gov/show/NCT04130789	Recruiting	University Hospital, Basel, Switzerland	2022-06-30
NCT03408600	Physiologic Indicators for Prognosis in Abdominal Sepsis Study	https://ClinicalTrials.gov/show/NCT03408600	Completed	World Society of Emergency Surgery	2018-05-01
NCT03378258	Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.	https://ClinicalTrials.gov/show/NCT03378258	Completed	Belfast Health and Social Care Trust	2019-06-30
NCT01319630	The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients	https://ClinicalTrials.gov/show/NCT01319630	Completed	Mercy Research	2013-12-31
NCT03870789	Field Paramedic Application of Sepsis Triage	https://ClinicalTrials.gov/show/NCT03870789	Recruiting	Hamilton Health Sciences Corporation	2019-05-01
NCT03355833	Comparing Prognostic Performance of SEPSIS 2 and SEPSIS 3 Strategies at the Emergency Service	https://ClinicalTrials.gov/show/NCT03355833	Completed	Centre Hospitalier Régional Metz-Thionville	2016-08-31
NCT03314831	The Role of Myristic Acid in Serum for Early Diagnosis of Sepsis and Comparison With Selected Biomarkers of Sepsis	https://ClinicalTrials.gov/show/NCT03314831	Recruiting	Charles University, Czech Republic	2019-12-31
NCT03310840	A Study On the Risk of Nosocomial Infection in Mechanically Ventilated Neonate In NICU of Assiut University Children Hospital (Nicu Eta)	https://ClinicalTrials.gov/show/NCT03310840	Completed	Assiut University	2019-03-30
NCT03280576	Validation of Progranulin as a Biomarker for Sepsis	https://ClinicalTrials.gov/show/NCT03280576	Completed	Ludwig-Maximilians - University of Munich	2019-04-30
NCT03249597	Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance	https://ClinicalTrials.gov/show/NCT03249597	Recruiting	Karolinska Institutet	2018-10-31
NCT03249246	Epidemiology of Sepsis in Turkish ICUs.	https://ClinicalTrials.gov/show/NCT03249246	Completed	Turkish Intensive Care Society	2016-01-28
NCT03244293	Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis	https://ClinicalTrials.gov/show/NCT03244293	Recruiting	Suez Canal University	2021-01-01
NCT03231956	CLEAR Sepsis Clinical Study	https://ClinicalTrials.gov/show/NCT03231956	Recruiting	Edwards Lifesciences	2021-12-31
NCT03226366	Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM)	https://ClinicalTrials.gov/show/NCT03226366	Completed	Intermountain Health Care, Inc.	2017-01-31
NCT03145428	Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis	https://ClinicalTrials.gov/show/NCT03145428	Completed	Beckman Coulter, Inc.	2017-12-22
NCT03141112	The Benefits of Early Initiation of Continual Renal Replacement Therapy in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT03141112	Enrolling by invitation	University Hospital Olomouc	2018-12-31
NCT03133208	Sepsis Associated Encephalopathy (SAE) Biomarkers	https://ClinicalTrials.gov/show/NCT03133208	Recruiting	University of Florida	2021-04-18
NCT03113721	Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis	https://ClinicalTrials.gov/show/NCT03113721	Active, not recruiting	Axis Shield Diagnostics Ltd	2018-12-31
NCT03077672	Mitochondrial DNA as a Biomarker of Sepsis Severity	https://ClinicalTrials.gov/show/NCT03077672	Recruiting	Weill Medical College of Cornell University	2021-12-31
NCT03076619	A Clinical Study of Fundus Findings in Toxaemia of Pregnancy	https://ClinicalTrials.gov/show/NCT03076619	Completed	B. J. Medical College, Ahmedabad	2006-06-30
NCT03037281	Release of Nociceptin From Granulocytes in Sepsis	https://ClinicalTrials.gov/show/NCT03037281	Completed	University of Leicester	2019-06-30
NCT03015584	Systems Biology Approach to Cognitive Impairment After SepsiS	https://ClinicalTrials.gov/show/NCT03015584	Completed	Intermountain Health Care, Inc.	2017-07-31
NCT03010410	Platelet Immune Responses in Aging and Influenza and Sepsis (INVACS)	https://ClinicalTrials.gov/show/NCT03010410	Enrolling by invitation	Intermountain Health Care, Inc.	2019-10-31
NCT02988414	Diagnosis of Bacteremia/Septicemia and Culture Negative Endocarditis by the Karius Sequencing-Based Infectious Disease Diagnostic Assay	https://ClinicalTrials.gov/show/NCT02988414	Completed	Karius, Inc.	2017-04-30
NCT02971111	Thromboelastometry in Assessment of Sepsis Coagulopathy	https://ClinicalTrials.gov/show/NCT02971111	Completed	University Hospital, Motol	2016-10-31
NCT02953002	The Correlation Between The New Sepsis Scores - SOFA, Quick SOFA and Calibrated Automated Thrombogram Values	https://ClinicalTrials.gov/show/NCT02953002	Recruiting	HaEmek Medical Center, Israel	2019-12-31
NCT02934997	The Role of Dysfunctional HDL in Sepsis	https://ClinicalTrials.gov/show/NCT02934997	Completed	University of Florida	2019-05-03
NCT02887274	Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02887274	Recruiting	Chang Gung Memorial Hospital	2018-12-31
NCT02739152	TRIAGE: TRIage of Sepsis At emerGency dEpartment	https://ClinicalTrials.gov/show/NCT02739152	Completed	BioMérieux	2018-01-31
NCT02738164	SEPSIS 3 Critera for Risk Stratification in Emergency Patients	https://ClinicalTrials.gov/show/NCT02738164	Completed	Societe Française de Medecine d’urgence	2016-07-31
NCT02730468	SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay	https://ClinicalTrials.gov/show/NCT02730468	Completed	Karius, Inc.	2017-09-30
NCT02728401	Genotypes and Phenotypes in Pediatric SIRS and Sepsis	https://ClinicalTrials.gov/show/NCT02728401	Completed	Seattle Children’s Hospital	2017-12-31
NCT02707718	Biomarkers for the Early Identification of Sepsis in the Emergency Department	https://ClinicalTrials.gov/show/NCT02707718	Completed	Pitié-Salpêtrière Hospital	2018-03-03
NCT02589431	Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02589431	Completed	TC Erciyes University	2011-06-30
NCT02569086	Piperacillin PK Analysis in Severe Sepsis Patients	https://ClinicalTrials.gov/show/NCT02569086	Completed	University of Aarhus	2016-06-30
NCT02562261	Platelet REactivity in Sepsis Syndrome (PRESS)	https://ClinicalTrials.gov/show/NCT02562261	Completed	University Hospital of Patras	2016-06-30
NCT02544490	Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis	https://ClinicalTrials.gov/show/NCT02544490	Completed	National University Hospital, Singapore	2018-12-31
NCT02533011	Evaluation of the Heparin Binding Protein Levels in Sepsis	https://ClinicalTrials.gov/show/NCT02533011	Completed	Christiana Care Health Services	2016-12-31
NCT02532959	Diagnostic Breath Analysis Study to Detect Sepsis	https://ClinicalTrials.gov/show/NCT02532959	Completed	Landon Pediatric Foundation	2015-09-30
NCT02539147	Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02539147	Completed	Groupe Hospitalier Paris Saint Joseph	2014-12-31
NCT02486783	Infection, Sepsis and Meningitis in Surinamese Neonates	https://ClinicalTrials.gov/show/NCT02486783	Completed	Academic Hospital Paramaribo	2016-08-31
NCT02444871	IgM-enriched Immunoglobulin Attenuates Systemic Endotoxin Activity in Early Severe Sepsis	https://ClinicalTrials.gov/show/NCT02444871	Completed	Goethe University	2013-07-31
NCT02448472	Epidemiology of Sepsis in China	https://ClinicalTrials.gov/show/NCT02448472	Completed	Southeast University, China	2015-12-31
NCT02430142	Microcirculatory Oxygen Uptake in Sepsis	https://ClinicalTrials.gov/show/NCT02430142	Completed	Universitätsmedizin Mannheim	2016-10-31
NCT02410486	Early-Onset Sepsis an NICHD/CDC Surveillance Study	https://ClinicalTrials.gov/show/NCT02410486	Completed	NICHD Neonatal Research Network	2017-12-31
NCT02393781	Adrenomedullin and Outcome in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02393781	Completed	Sphingotec GmbH	2016-05-31
NCT02370186	The Role of Dysfunctional HDL in Severe Sepsis	https://ClinicalTrials.gov/show/NCT02370186	Completed	University of Florida	2017-03-12
NCT02353910	VTE Incidence in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02353910	Completed	University of Utah	2014-12-31
NCT02288715	Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy	https://ClinicalTrials.gov/show/NCT02288715	Completed	West China Hospital	2015-03-31
NCT02281890	Neurodevelopmental Outcomes After Suspected or Proven Sepsis: Secondary Analysis of INIS Trial Database	https://ClinicalTrials.gov/show/NCT02281890	Completed	University of Edinburgh	2007-09-30
NCT02217592	Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand	https://ClinicalTrials.gov/show/NCT02217592	Completed	University of Oxford	2017-02-28
NCT02188992	Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study	https://ClinicalTrials.gov/show/NCT02188992	Completed	University of Edinburgh	2016-01-31
NCT02157259	An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis in Southeast Asia	https://ClinicalTrials.gov/show/NCT02157259	Completed	University of Oxford	2016-02-29
NCT02026856	Therapeutic Effect of Sodium Selenite on Oxidative Stress in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02026856	Completed	Pavol Jozef Safarik University	2013-12-31
NCT01995448	Prognostic Interest of Leucocyte Immunophenotyping During the Acute Phase of Sepsis	https://ClinicalTrials.gov/show/NCT01995448	Completed	University Hospital, Limoges	2015-06-30
NCT01968746	The AVERT Sepsis Investigation	https://ClinicalTrials.gov/show/NCT01968746	Completed	Christiana Care Health Services	2015-01-31
NCT01964690	Lactate Use as Triage Tool in Sepsis : Veinous, Capillary or Arterial?	https://ClinicalTrials.gov/show/NCT01964690	Completed	Hopital Saint Roch	2014-04-30
NCT01943747	International Multicentre Prevalence Study on Sepsis	https://ClinicalTrials.gov/show/NCT01943747	Completed	European Society of Intensive Care Medicine	2013-11-30
NCT01929772	German Lactat Clearance in Severe Sepsis	https://ClinicalTrials.gov/show/NCT01929772	Completed	RWTH Aachen University	2015-04-30
NCT01919138	Outcomes of Severe Sepsis Patients in Surgical Intensive Care Units	https://ClinicalTrials.gov/show/NCT01919138	Completed	National Taiwan University Hospital	2013-12-31
NCT01867905	Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT01867905	Completed	University of British Columbia	2018-09-05
NCT02025699	Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis	https://ClinicalTrials.gov/show/NCT02025699	Completed	MeMed Diagnostics Ltd.	2016-06-30
NCT01847248	HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis	https://ClinicalTrials.gov/show/NCT01847248	Completed	Changhai Hospital	2013-03-31
NCT01725061	Study of the Function of Cells Involved in Inflammation in the Lungs of Those With Acute Lung Injury and Sepsis	https://ClinicalTrials.gov/show/NCT01725061	Completed	Emory University	2012-09-30
NCT01670383	Repository for Sepsis and Postresuscitation Samples	https://ClinicalTrials.gov/show/NCT01670383	Recruiting	Seoul National University Hospital	2020-12-31
NCT01649440	Sepsis Metabolomics	https://ClinicalTrials.gov/show/NCT01649440	Completed	Chinese PLA General Hospital	2012-03-31
NCT01578226	Procalcitonin in Cirrhotic Patients at High Risk for Sepsis	https://ClinicalTrials.gov/show/NCT01578226	Completed	University of Modena and Reggio Emilia	2010-09-30
NCT00806325	Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia	https://ClinicalTrials.gov/show/NCT00806325	Completed	Ohio State University	2010-02-28
NCT01530932	Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin	https://ClinicalTrials.gov/show/NCT01530932	Completed	Universitätsmedizin Mannheim	2014-04-30
NCT01530854	Plasma Free Fatty Acids in Risk Assessment of Sepsis in the Emergency Department: A Prospective Pilot Study	https://ClinicalTrials.gov/show/NCT01530854	Completed	The Cleveland Clinic	2012-01-31
NCT01523717	Procalcitonin Monitoring Sepsis Study	https://ClinicalTrials.gov/show/NCT01523717	Completed	Brahms AG	2014-03-31
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	https://ClinicalTrials.gov/show/NCT01431326	Completed	Duke University	2019-11-30
NCT01426711	Critical Care Excellence in Sepsis and Trauma	https://ClinicalTrials.gov/show/NCT01426711	Completed	Medical University of South Carolina	2012-03-31
NCT01410578	The Value of sTREM-1, PCT, and CRP as Markers for the Detection of Sepsis and Bacteremia Among Patients With a FUO	https://ClinicalTrials.gov/show/NCT01410578	Completed	Chinese PLA General Hospital	2011-03-31
NCT01403935	Sepsis Institutional Registry in Hospital Italiano de Buenos Aires	https://ClinicalTrials.gov/show/NCT01403935	Completed	Hospital Italiano de Buenos Aires	2014-03-31
NCT01388725	Comparison the Value of Several Biomarkers of Sepsis	https://ClinicalTrials.gov/show/NCT01388725	Completed	Chinese PLA General Hospital	2011-07-31
NCT01378169	SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU	https://ClinicalTrials.gov/show/NCT01378169	Completed	Groupe Hospitalier Paris Saint Joseph	2013-01-01
NCT01362829	Outcome Predictors in Patients With Severe Sepsis and Optimized Central Venous Oxygen Saturation	https://ClinicalTrials.gov/show/NCT01362829	Completed	National Taiwan University Hospital	2011-05-31
NCT01333657	The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries	https://ClinicalTrials.gov/show/NCT01333657	Completed	Chinese PLA General Hospital	2011-04-30
NCT01332734	Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis	https://ClinicalTrials.gov/show/NCT01332734	Completed	Medical Centre Leeuwarden	2010-08-31
NCT01328509	Zinc and Inflammation in Sepsis	https://ClinicalTrials.gov/show/NCT01328509	Completed	University of Aberdeen	2013-05-31
NCT03412552	Risk Analysis of Intensive Care Mangement on Maternal and Fetal Outcome of Severe Preeclampsia and Eclampsia	https://ClinicalTrials.gov/show/NCT03412552	Completed	Cairo University	2017-10-01
NCT03620409	Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis	https://ClinicalTrials.gov/show/NCT03620409	Recruiting	Jena University Hospital	2020-12-31
NCT04353388	Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Washington University	https://ClinicalTrials.gov/show/NCT04353388	Recruiting	Beckman Coulter, Inc.	2020-05-31
NCT04322942	Sepsis Prediction by Monocyte Distribution Width and Procalcitonin	https://ClinicalTrials.gov/show/NCT04322942	Recruiting	Chang Gung Memorial Hospital	2020-09-30
NCT04291417	Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Baylor S&W	https://ClinicalTrials.gov/show/NCT04291417	Recruiting	Beckman Coulter, Inc.	2020-04-30
NCT04289506	Validation of Molecular and Protein Biomarkers in Sepsis	https://ClinicalTrials.gov/show/NCT04289506	Recruiting	Public Health England	2021-11-30
NCT04214743	Ocular Microvascular Changes in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT04214743	Completed	Lithuanian University of Health Sciences	2019-08-31
NCT04199962	Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis	https://ClinicalTrials.gov/show/NCT04199962	Recruiting	Chinese University of Hong Kong	2022-11-11
NCT04157452	Prediction of Sepsis After Flexible Ureteroscopy	https://ClinicalTrials.gov/show/NCT04157452	Completed	Tongji Hospital	2019-08-01
NCT04149132	Pulse Photoplethysmography as an Early Tool for the Diagnosis of Sepsis	https://ClinicalTrials.gov/show/NCT04149132	Active, not recruiting	Hellenic Institute for the Study of Sepsis	2020-05-08
NCT04141410	Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis	https://ClinicalTrials.gov/show/NCT04141410	Recruiting	Azienda USL Toscana Centro	2020-10-21
NCT04126629	Association of Hypertensive Disorder of Pregnancy With Sleep-disordered Breathing.	https://ClinicalTrials.gov/show/NCT04126629	Recruiting	The Cooper Health System	2020-09-01
NCT04118179	New Strategy to Predict Early Sepsis	https://ClinicalTrials.gov/show/NCT04118179	Recruiting	University of British Columbia	2020-07-31
NCT04117568	The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients	https://ClinicalTrials.gov/show/NCT04117568	Recruiting	Göteborg University	2020-12-31
NCT04114214	Objective Sepsis Identification Tool to Study Sepsis Epidemiology	https://ClinicalTrials.gov/show/NCT04114214	Completed	Chinese University of Hong Kong	2019-10-10
NCT04105699	Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis	https://ClinicalTrials.gov/show/NCT04105699	Recruiting	Abionic SA	2020-07-31
NCT04094818	HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis	https://ClinicalTrials.gov/show/NCT04094818	Enrolling by invitation	Inflammatix	2021-10-31
NCT04068298	Temperature Gradients for Sepsis Severity and Fluid Resuscitation	https://ClinicalTrials.gov/show/NCT04068298	Recruiting	Nanfang Hospital of Southern Medical University	2022-09-01
NCT04063332	Functionality of Endogenous Biological Clock in Sepsis	https://ClinicalTrials.gov/show/NCT04063332	Recruiting	University of Athens	2020-06-30
NCT04055727	Sepsis at Södersjukhuset-Adherence to Treatment Guidelines	https://ClinicalTrials.gov/show/NCT04055727	Recruiting	Karolinska Institutet	2021-12-01
NCT04033653	Long-term Quality of Life Among Survivors of Sepsis in China Assessed by EQ-5D	https://ClinicalTrials.gov/show/NCT04033653	Completed	Southeast University, China	2018-08-31
NCT04032743	Risk Factors and Treatment Outcome of Oncology Children Hospitalized in the Intensive Care Unit Due to Sepsis	https://ClinicalTrials.gov/show/NCT04032743	Active, not recruiting	Rabin Medical Center	2020-07-31
NCT04028102	Ultrasound Optimization of Initial Fluid Challenge in Sepsis	https://ClinicalTrials.gov/show/NCT04028102	Recruiting	Nantes University Hospital	2020-03-01
NCT03996759	Early Prediction of Sepsis by Using Metabolomics	https://ClinicalTrials.gov/show/NCT03996759	Recruiting	Southwest Hospital, China	2021-06-18
NCT03960307	Glycocalyx and Microcirculation in Sepsis	https://ClinicalTrials.gov/show/NCT03960307	Completed	University Hospital Muenster	2017-09-30
NCT03952390	Effect of Renin-Angiotensin System on Platelet in Patient With Sepsis	https://ClinicalTrials.gov/show/NCT03952390	Completed	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	2019-12-10
NCT03938220	Electrical Cardiometry Compared to Transthoracic Echocardiography in Fluid Responsiveness in Sepsis	https://ClinicalTrials.gov/show/NCT03938220	Recruiting	Tanta University	2020-04-01
NCT03932123	Antibiotic Therapy for Early Onset Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT03932123	Recruiting	Shandong University	2025-10-31
NCT03884894	Neonatal Sepsis Diagnosis: ; PCR Commercial Technique and Blood Culture	https://ClinicalTrials.gov/show/NCT03884894	Completed	IRCCS Policlinico S. Matteo	2016-01-31
NCT03884595	Early Identification of Sepsis in Children	https://ClinicalTrials.gov/show/NCT03884595	Recruiting	Brno University Hospital	2021-12-31
NCT03881566	Presepsin as Detective Marker of Sepsis in Immunodeficiency ICU Patients	https://ClinicalTrials.gov/show/NCT03881566	Recruiting	Seoul St. Mary’s Hospital	2020-12-31
NCT03803813	Incidence of Sepsis After Craniocerebral Operation	https://ClinicalTrials.gov/show/NCT03803813	Active, not recruiting	Beijing Tiantan Hospital	2018-12-31
NCT03802136	Multiple Biomarkers in ICU Sepsis Patients	https://ClinicalTrials.gov/show/NCT03802136	Recruiting	Zhongnan Hospital	2019-06-30
NCT03799159	Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury	https://ClinicalTrials.gov/show/NCT03799159	Recruiting	Alexandria University	2020-06-30
NCT03796715	Red Cell Distribution Width Versus Presepsin (Soluble CD14) as a Prognostic Marker in Critically-ill Sepsis Patients	https://ClinicalTrials.gov/show/NCT03796715	Completed	Ain Shams University	2018-11-20
NCT03782454	Quantification of Bacterial DNA in Sepsis	https://ClinicalTrials.gov/show/NCT03782454	Recruiting	Region Örebro County	2021-12-31
NCT03777670	nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis	https://ClinicalTrials.gov/show/NCT03777670	Recruiting	Cardiff and Vale University Health Board	2023-02-28
NCT03744741	HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study	https://ClinicalTrials.gov/show/NCT03744741	Completed	Inflammatix	2019-11-25
NCT03721302	NeoAMR Observational Study in Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT03721302	Recruiting	Drugs for Neglected Diseases	2019-12-31
NCT03708796	DIAGNOSis of Infection in Emergency Department	https://ClinicalTrials.gov/show/NCT03708796	Completed	Association pour la Formation l’Enseignement et la Recherche du Service de l’Accueil des Urgences	2018-04-13
NCT03682003	Hepcidin: a Prognostic Marker of Morbidity and Mortality in Severe Sepsis?	https://ClinicalTrials.gov/show/NCT03682003	Active, not recruiting	Rennes University Hospital	2017-07-12
NCT03661450	Evaluation of CDSS in Detection of SIRS and Sepsis in Pediatric Patients	https://ClinicalTrials.gov/show/NCT03661450	Completed	Hannover Medical School	2019-03-31
NCT03654456	Impact of Sleep Apnea on Sepsis Mortality	https://ClinicalTrials.gov/show/NCT03654456	Recruiting	Taipei Veterans General Hospital, Taiwan	2019-05-27
NCT03641534	Monitoring of Perfusion in Sepsis and Malaria	https://ClinicalTrials.gov/show/NCT03641534	Recruiting	University of Oxford	2019-09-30
NCT03623503	Clinical Criteria for a Pathogen in Term Newborn Suspected of Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT03623503	Completed	Centre Hospitalier Universitaire, Amiens	2017-07-12
NCT02276417	PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors	https://ClinicalTrials.gov/show/NCT02276417	Recruiting	University of Florida	2020-07-31
NCT03598127	Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity	https://ClinicalTrials.gov/show/NCT03598127	Recruiting	West China Hospital	2020-04-01
NCT03588325	Evaluation of MDW for Early Detection of Sepsis, Clinical Validity	https://ClinicalTrials.gov/show/NCT03588325	Completed	Beckman Coulter, Inc.	2019-08-02
NCT03584594	Presepsin in the Diagnosis of Sepsis in Critically Ill Patients	https://ClinicalTrials.gov/show/NCT03584594	Recruiting	University Hospital Ostrava	2021-12-31
NCT03578978	A Panel of Biomarkers in Diagnosing Late-onset Neonatal Sepsis and Necrotizing Enterocolitis in Sibu Hospital	https://ClinicalTrials.gov/show/NCT03578978	Recruiting	Clinical Research Centre, Malaysia	2020-05-31
NCT03540797	Myeloid-derived Suppressor Cells in Sepsis	https://ClinicalTrials.gov/show/NCT03540797	Recruiting	Chang Gung Memorial Hospital	2023-12-31
NCT03506152	Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis	https://ClinicalTrials.gov/show/NCT03506152	Completed	Aga Khan University	2015-12-03
NCT03489447	Mortality of Sepsis in Swedish Intensive Care Units 2008-2016	https://ClinicalTrials.gov/show/NCT03489447	Completed	Uppsala University	2017-10-25
NCT03474809	Early Diagnostic of Sepsis and Potential Impact on Antibiotic Management Based on Serial.Pancreatic Stone Protein (PSP) Measured Using the AbioScope.	https://ClinicalTrials.gov/show/NCT03474809	Completed	Abionic SA	2019-03-15
NCT03433846	Predictors of Sepsis in Ex-Preterm Infants	https://ClinicalTrials.gov/show/NCT03433846	Recruiting	Boston Children’s Hospital	2020-04-01
NCT01236703	Hematological Infection Score Compared to the Hospital Standard for Diagnosis of SIRS or Sepsis on ICU	https://ClinicalTrials.gov/show/NCT01236703	Completed	Charite University, Berlin, Germany	2010-05-31
NCT01128283	Indicators of Inflammation and Coagulation in Sepsis	https://ClinicalTrials.gov/show/NCT01128283	Completed	University of Oklahoma	2014-05-31
NCT01120678	Improved Detection of Neonatal Sepsis Using a Targeted Biomarker Assay	https://ClinicalTrials.gov/show/NCT01120678	Completed	University of Virginia	2010-07-31
NCT01029080	Cerebrovascular Autoregulation During Sepsis	https://ClinicalTrials.gov/show/NCT01029080	Completed	Johannes Gutenberg University Mainz	2010-12-31
NCT01012115	Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis	https://ClinicalTrials.gov/show/NCT01012115	Completed	University of Oklahoma	2011-09-30
NCT00874367	Early-Onset Sepsis Surveillance Study	https://ClinicalTrials.gov/show/NCT00874367	Completed	NICHD Neonatal Research Network	2009-12-31
NCT00862290	Circulating microRNAs as Biomarkers of Sepsis	https://ClinicalTrials.gov/show/NCT00862290	Completed	Changhai Hospital	2009-04-30
NCT03780712	Immune Dysfunction in Newborn Sepsis	https://ClinicalTrials.gov/show/NCT03780712	Completed	BioMérieux	2018-03-12
NCT01392508	IMproved PREdiction of Severe Sepsis in the Emergency Department	https://ClinicalTrials.gov/show/NCT01392508	Completed	Axis Shield Diagnostics Ltd	2015-09-30
NCT00835913	Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact	https://ClinicalTrials.gov/show/NCT00835913	Completed	University Hospital, Grenoble	2011-09-30
NCT03727243	Molecular Diagnosis and Risk Stratification of Sepsis in India	https://ClinicalTrials.gov/show/NCT03727243	Recruiting	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2020-07-31
NCT03201679	The Association Between Preoperative Sepsis and the Mortality After Hip Fracture Surgery	https://ClinicalTrials.gov/show/NCT03201679	Completed	Bispebjerg Hospital	2015-01-30
NCT00811629	Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients	https://ClinicalTrials.gov/show/NCT00811629	Completed	University Hospital, Clermont-Ferrand	2009-07-31
NCT01362504	Pro-adrenomedullin as a Prognostic Marker in Neonatal Sepsis	https://ClinicalTrials.gov/show/NCT01362504	Completed	Zekai Tahir Burak Women’s Health Research and Education Hospital	2011-08-31
NCT04026035	PCR Technic Evaluation in the Microbial Diagnostic of Septicemia in Hemodialysis Patients With Catheter.	https://ClinicalTrials.gov/show/NCT04026035	Completed	University Hospital, Bordeaux	2020-03-05
NCT03379402	Sepsis-3 Study in Northeast Thailand	https://ClinicalTrials.gov/show/NCT03379402	Recruiting	University of Oxford	2020-06-30
NCT02883218	Dynamic Alterations of Th2/Th1 With New Onset of Community-acquired Severe Sepsis Patients	https://ClinicalTrials.gov/show/NCT02883218	Completed	Southeast University, China	2018-07-20
NCT02170233	SHOCK US STUDY: Fluid Responsiveness in Sepsis Measured by Ultrasonography	https://ClinicalTrials.gov/show/NCT02170233	Completed	Yale University	2016-06-30
NCT02052895	Utility of Presepsin in Distinguishing Between Sepsis and SIRS	https://ClinicalTrials.gov/show/NCT02052895	Completed	Mochida Pharmaceutical Company, Ltd.	2015-07-31
NCT04441944	TELEmedicine as an Intervention for Sepsis in Emergency Departments	https://ClinicalTrials.gov/show/NCT04441944	Recruiting	University of Iowa	2019-06-30
NCT03953404	POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT03953404	Recruiting	St. Luke’s Hospital, Pennsylvania	2020-04-30
NCT00793442	Endothelium in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00793442	Completed	Beth Israel Deaconess Medical Center	2013-05-31
NCT00781040	Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients	https://ClinicalTrials.gov/show/NCT00781040	Completed	Kuopio University Hospital	2019-01-01
NCT00736723	NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock	https://ClinicalTrials.gov/show/NCT00736723	Completed	University of Ulm	2012-08-31
NCT00698048	Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00698048	Completed	KK Women’s and Children’s Hospital	2011-12-31
NCT00615862	Relationship Between Alcohol Use Disorders and Cortisol Levels in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT00615862	Completed	Virginia Commonwealth University	2009-05-31
NCT00561639	Benefit of SeptiFast Multiplex PCR in the Etiologic Diagnosis and Therapeutic Approach for Onco-hematology Patients Presenting Sepsis	https://ClinicalTrials.gov/show/NCT00561639	Completed	University Hospital, Grenoble	NA
NCT00541827	Skeletal Muscle and Platelet Mitochondrial Dysfunction During Sepsis	https://ClinicalTrials.gov/show/NCT00541827	Completed	Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico	2011-08-31
NCT00488917	Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)	https://ClinicalTrials.gov/show/NCT00488917	Completed	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	2009-08-31
NCT00448968	The Utility of Ischemia Modified Albumin (IMA) in Sepsis	https://ClinicalTrials.gov/show/NCT00448968	Completed	Inverness Medical Innovations	NA
NCT00005207	Renin and Prorenin in Pregnancy	https://ClinicalTrials.gov/show/NCT00005207	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA
NCT00229034	Effect of APC and Epo on the Inflammatory Response During Sepsis	https://ClinicalTrials.gov/show/NCT00229034	Completed	Lawson Health Research Institute	2010-12-31
NCT00185783	Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00185783	Completed	Stanford University	2006-11-30
NCT00175526	Predicting Complications in Women With Toxaemia	https://ClinicalTrials.gov/show/NCT00175526	Completed	University of British Columbia	2010-12-31
NCT00005208	Regulation of Placental Vascular Reactivity in Pregnancy-induced Hypertension	https://ClinicalTrials.gov/show/NCT00005208	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03158493	Assessment of qSOFA in the Latin America Sepsis Institute Database	https://ClinicalTrials.gov/show/NCT03158493	Completed	Federal University of São Paulo	2017-03-31
NCT03029039	Platelet-associated Inflammation in Severe Sepsis	https://ClinicalTrials.gov/show/NCT03029039	Recruiting	Centre Hospitalier Universitaire de Saint Etienne	2020-06-30
NCT02936232	Severe Sepsis and Septic Shock Registry	https://ClinicalTrials.gov/show/NCT02936232	Recruiting	Seoul National University Hospital	2022-03-31
NCT02605681	Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis	https://ClinicalTrials.gov/show/NCT02605681	Completed	Southeast University, China	2018-03-31
NCT02238795	Sepsis-Associated Purpura Fulminans International Registry - Europe	https://ClinicalTrials.gov/show/NCT02238795	Recruiting	Jena University Hospital	2019-12-31
NCT02180009	Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT02180009	Completed	Chinese PLA General Hospital	2015-08-31
NCT02020174	The Preeclampsia Registry	https://ClinicalTrials.gov/show/NCT02020174	Recruiting	Preeclampsia Foundation	2030-05-31
NCT01947127	Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department	https://ClinicalTrials.gov/show/NCT01947127	Completed	Chulalongkorn University	2014-11-30
NCT04292431	Leukocyte MOrphology and CORticosteroids Response in SEPtic Patients (MOCORSEP)	https://ClinicalTrials.gov/show/NCT04292431	Recruiting	Beckman Coulter, Inc.	2020-06-30
NCT04226430	Effect of Cytosorb on Blood Levels of Inflammatory Biomarkers of Sepsis.	https://ClinicalTrials.gov/show/NCT04226430	Completed	University of Gaziantep	2017-06-30
NCT04203979	Sepsis: From Syndrome to Personalized Care	https://ClinicalTrials.gov/show/NCT04203979	Recruiting	Oslo University Hospital	2020-12-31
NCT04135274	Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Neural Tube Defects?	https://ClinicalTrials.gov/show/NCT04135274	Completed	Tepecik Training and Research Hospital	2018-12-30
NCT03996720	Early Identification and Effective Management of Pediatric Sepsis	https://ClinicalTrials.gov/show/NCT03996720	Recruiting	Children’s Hospital of Fudan University	2020-12-31
NCT03956043	Diagnostic Accuracy in Sepsis	https://ClinicalTrials.gov/show/NCT03956043	Recruiting	Oslo University Hospital	2021-05-15
NCT03943719	Clinical Impact of the FilmArray Blood Culture Identification Panel Performed on Positive Blood Cultures From Intensive Care Patients With Septicemia	https://ClinicalTrials.gov/show/NCT03943719	Completed	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	2017-12-31
NCT03923543	Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease	https://ClinicalTrials.gov/show/NCT03923543	Completed	Tepecik Training and Research Hospital	2018-12-31
NCT03883061	Mathematical Modeling and Risk Factor Analysis for Mortality of Sepsis	https://ClinicalTrials.gov/show/NCT03883061	Recruiting	Shanghai Tongji Hospital, Tongji University School of Medicine	2019-03-01
NCT03789838	Effect of Sepsis Response Team in the Emergency Department	https://ClinicalTrials.gov/show/NCT03789838	Completed	Oslo University Hospital	2018-05-15
NCT03634891	An Audit Study on Management of Neonates With Neonatal Sepsis Admitted to Asyut University Children Hospital	https://ClinicalTrials.gov/show/NCT03634891	Recruiting	Assiut University	2019-06-01
NCT03523169	Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis	https://ClinicalTrials.gov/show/NCT03523169	Completed	Peking Union Medical College Hospital	2017-11-01
NCT04448951	Immune Homeostasis in Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT04448951	Recruiting	Charles University, Czech Republic	2021-12-31